Brian C. Yowler

Disciplines/Field of Instruction

Degrees Received

Ph.D. (Biochemistry and Molecular Biology), August 2002, Penn State University College of Medicine
B.S. (Biology), December 1994, Indiana University of Pennsylvania

Courses Taught

Presentations/Publications

Petro, K.A., Dyer, M.A., Yowler, B.C., and Schengrund, C-L. Disruption of lipid rafts enhances activity of botulinum neurotoxin serotype A. Toxicon. 48: 1035-1045. (2006)
Yowler, B.C., and Schengrund, C-L. Glycosphingolipids-Sweets for botulinum neurotoxin. Glycoconjugate Journal. 21: 285-291. (2004)
Yowler, B.C., and Schengrund, C-L. Kinetic analysis of the interaction of Botulinum neurotoxin with ganglioside GT1b. Biochemistry 43: 9725-31. (2004)
Kensinger, R.D., Yowler, B.C., Benesi, A.J., Schengrund, C-L. Synthesis of novel, multivalent, glycodendrimers as Ligands for HIV-1 gp120. Bioconjugate Chemistry 15:349-58. (2004)
Yowler, B.C., Kensinger, R.D., and Schengrund, C-L. Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I. Journal of Biological Chemistry 277:32815-32819. (2002)
Yowler, B.C., Stoehr, S.A., and Schengrund, C-L. Oxidation and base-catalyzed elimination of the saccharide portion of GSLs having very different polarities. Journal of Lipid Research 42:659-662. (2001)
Ropson, I.J., Yowler, B.C., Dalessio, P.M., Banaszak, L.B., and Thompson, J. Properties and Crystal Structure of a B-Barrel Folding Mutant. Biophysical Journal 78:1551-1560. (2000)

Current Projects

Research on Recovery from Botulinum Toxin Paralysis: This project attempts to determine whether there is a difference in time of onset or time of recovery from leg paralysis due to botulinum toxin poisoning in running vs. non-running mice.

Miscellaneous, e.g., hobbies, sports, personal info, etc.

Currently an Assistant Coach for Men’s and Women’s Cross Country and Track and Field
Married with 2 young children
Enjoy distance running - have raced 9 marathons and counting (including Boston)
Avid Pittsburgh Sports fan