Geneva College

 

 

Brian C. Yowler

Brian YowlerOffice Phone: 724-847-6728
bcyowler@geneva.edu          

Disciplines/Field of Instruction

  • Biochemistry/Biology

Degrees Received

  • Ph.D. (Biochemistry and Molecular Biology), August 2002, Penn State University College of Medicine
  • B.S. (Biology), December 1994, Indiana University of Pennsylvania

Courses Taught

  • BIO 101 - Bioterrorism
  • BIO 112 - Cell Biology
  • BIO 316 - Virology
  • BIO 319 - Genetics
  • BIO 405 - Molecular Biology

Presentations/Publications

  • M. Blome, B.C. Yowler, R. O'Keeffe, N. Panjwani, A.M. Pickett, and C-L. Schengrund. (2008) Use of surface plasmon resonance to characterize binding of botulinum type A toxin-haemagglutinin complex to gangliosides. The Botulinum Journal.
  • Petro, K.A., Dyer, M.A., Yowler, B.C., and Schengrund, C-L.  Disruption of lipid rafts enhances activity of botulinum neurotoxin serotype A. Toxicon. 48: 1035-1045. (2006)
  • Yowler, B.C., and Schengrund, C-L. Glycosphingolipids-Sweets for botulinum neurotoxin. Glycoconjugate Journal. 21: 285-291. (2004)
  • Yowler, B.C., and Schengrund, C-L. Kinetic analysis of the interaction of Botulinum neurotoxin with ganglioside GT1b. Biochemistry 43: 9725-31. (2004)
  • Kensinger, R.D., Yowler, B.C., Benesi, A.J., Schengrund, C-L. Synthesis of novel, multivalent, glycodendrimers as Ligands for HIV-1 gp120.  Bioconjugate Chemistry 15:349-58. (2004)
  • Yowler, B.C., Kensinger, R.D., and Schengrund, C-L.  Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I.  Journal of Biological Chemistry 277:32815-32819. (2002)
  • Yowler, B.C., Stoehr, S.A., and Schengrund, C-L.  Oxidation and base-catalyzed elimination of the saccharide portion of GSLs having very different polarities. Journal of Lipid Research 42:659-662. (2001)
  • Ropson, I.J., Yowler, B.C., Dalessio, P.M., Banaszak, L.B., and Thompson, J.  Properties and Crystal Structure of a B-Barrel Folding Mutant. Biophysical Journal 78:1551-1560. (2000)

Current Projects

  • Research on Recovery from Botulinum Toxin Paralysis: This project attempts to determine whether there is a difference in time of onset or time of recovery from leg paralysis due to botulinum toxin poisoning in running vs. non-running mice.
  • Research on the detection of CAEV, an HIV-like virus in dairy goats. This project involves testing a variety of bodily fluids to determine the possible routes of transmission of the virus.  

Miscellaneous, e.g., hobbies, sports, personal info, etc.

  • Currently the Head Coach for Men’s and Women’s Cross Country and Track and Field
  • Married with 2 young children
  • Enjoy distance running - have raced 17 marathons and counting (including Boston)
  • Avid Pittsburgh Sports fan

 

Point of Excellence

Geneva’s biochemistry major is approved by the American Chemical Society and offers rigorous preparation for graduate or allied-health schools.

more points >>
 
Upcoming Events
Oct26
Reformation Day Service
Metheney Fieldhouse 6:30 p.m.

Nov01
Geneva Alumni & Friends visit "Annie" at The Benedum
Benedum Center, Pittsburgh 2:00 p.m.

STUDENTS
Geneva partners with Zipcar to offer car sharing
New program provides students a cost effective and sustainable alternative to car ownership on campus.
SERVICE
Service opportunities in Beaver Falls
Students can work with Tiger Pause and the Dare2XL programs.
CURRENT STUDENTS
Branches on campus
The Christian indie/folk band is kicking off the Three Past Three program on October 23.
COMMUNITY
Living in Color: Steppin’ Up—Moving from Theory to Action
The conference, which focuses on getting involved in multicultural issues, will be held Nov. 7-8.
GRADUATE PROGRAMS
MBA program to host Open House
An information session that includes a complementary dinner will be held at the Cranberry Regional Learning Alliance on Tue., Oct. 28.