Geneva College

 
Brian C. Yowler

Brian YowlerOffice Phone: 724-847-6728
bcyowler@geneva.edu          

Disciplines/Field of Instruction

  • Biochemistry/Biology

Degrees Received

  • Ph.D. (Biochemistry and Molecular Biology), August 2002, Penn State University College of Medicine
  • B.S. (Biology), December 1994, Indiana University of Pennsylvania

Courses Taught

  • BIO 101 - Bioterrorism
  • BIO 112 - Cell Biology
  • BIO 316 - Virology
  • BIO 319 - Genetics
  • BIO 405 - Molecular Biology

Presentations/Publications

  • M. Blome, B.C. Yowler, R. O'Keeffe, N. Panjwani, A.M. Pickett, and C-L. Schengrund. (2008) Use of surface plasmon resonance to characterize binding of botulinum type A toxin-haemagglutinin complex to gangliosides. The Botulinum Journal.
  • Petro, K.A., Dyer, M.A., Yowler, B.C., and Schengrund, C-L.  Disruption of lipid rafts enhances activity of botulinum neurotoxin serotype A. Toxicon. 48: 1035-1045. (2006)
  • Yowler, B.C., and Schengrund, C-L. Glycosphingolipids-Sweets for botulinum neurotoxin. Glycoconjugate Journal. 21: 285-291. (2004)
  • Yowler, B.C., and Schengrund, C-L. Kinetic analysis of the interaction of Botulinum neurotoxin with ganglioside GT1b. Biochemistry 43: 9725-31. (2004)
  • Kensinger, R.D., Yowler, B.C., Benesi, A.J., Schengrund, C-L. Synthesis of novel, multivalent, glycodendrimers as Ligands for HIV-1 gp120.  Bioconjugate Chemistry 15:349-58. (2004)
  • Yowler, B.C., Kensinger, R.D., and Schengrund, C-L.  Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I.  Journal of Biological Chemistry 277:32815-32819. (2002)
  • Yowler, B.C., Stoehr, S.A., and Schengrund, C-L.  Oxidation and base-catalyzed elimination of the saccharide portion of GSLs having very different polarities. Journal of Lipid Research 42:659-662. (2001)
  • Ropson, I.J., Yowler, B.C., Dalessio, P.M., Banaszak, L.B., and Thompson, J.  Properties and Crystal Structure of a B-Barrel Folding Mutant. Biophysical Journal 78:1551-1560. (2000)

Current Projects

  • Research on Recovery from Botulinum Toxin Paralysis: This project attempts to determine whether there is a difference in time of onset or time of recovery from leg paralysis due to botulinum toxin poisoning in running vs. non-running mice.
  • Research on the detection of CAEV, an HIV-like virus in dairy goats. This project involves testing a variety of bodily fluids to determine the possible routes of transmission of the virus.  

Miscellaneous, e.g., hobbies, sports, personal info, etc.

  • Currently the Head Coach for Men’s and Women’s Cross Country and Track and Field
  • Married with 2 young children
  • Enjoy distance running - have raced 17 marathons and counting (including Boston)
  • Avid Pittsburgh Sports fan

http://www.geneva.edu/object/faculty_brian_yowler.html

Geneva College | 3200 College Ave., Beaver Falls, PA 15010